Adjunctive Therapy of Allergic Bronchopulmonary Aspergillosis with...
Case 6 This 47-year-old patient had had asthma, eczema, and allergic rhinitis since the age of four years. Bronchiectasis of the left upper lobe was diagnosed at the age of 21 years concurrent with...
View ArticleAdjunctive Therapy of Allergic Bronchopulmonary Aspergillosis with...
She was treated with itraconazole (200 mg twice daily). About ten days after starting itraconazole therapy, the patient started to cough up large quantities of brown mucus, which gradually cleared...
View ArticleAdjunctive Therapy of Allergic Bronchopulmonary Aspergillosis with...
All patients experienced improvement in their pulmonary function (Table 1). Among those treated for at least two months, FEVi rose from a mean of 1.43 Us (Cl, 0.84 to 2.1 Us) to 1.79 Us (Cl, 1.18 to...
View ArticleAdjunctive Therapy of Allergic Bronchopulmonary Aspergillosis with...
Mean steady-state serum concentrations of itraconazole were 5.3 jig/ml, 1.8 |xg/ml, 4.2 |xg/ml, 7.2 iLg/ml, 7.3 jig/ml, and 4.8 jxg/ml (mean, 5.1 |xg/ ml) in patients 1, 2, 3, 4, 5, and 6,...
View ArticleAdjunctive Therapy of Allergic Bronchopulmonary Aspergillosis with...
Discussion This report documents improvement in clinical, serologic, and pulmonary functional status with itraconazole therapy in ABPA. Itraconazole is a new orally administered triazole antifungal...
View ArticleAdjunctive Therapy of Allergic Bronchopulmonary Aspergillosis with...
It may be that serum concentrations (possibly reflecting pulmonary parenchymal concentrations) are more important than sputum concentrations in determining efficacy. Improvement in symptomatic...
View ArticleAdjunctive Therapy of Allergic Bronchopulmonary Aspergillosis with...
The total serum IgE level fell substantially in all patients except patient 2 during itraconazole therapy and remained low without therapy in two (patient 3 for three months and patient 4 for two...
View ArticleAdjunctive Therapy of Allergic Bronchopulmonary Aspergillosis with...
In five patients, precipitating (IgG) antibody to Aspergillus persisted during therapy; in one (patient 5), antibody became undetectable by immunodiffusion. As the immunodiffusion technique used is...
View ArticleAdjunctive Therapy of Allergic Bronchopulmonary Aspergillosis with...
Clearly, sputum culture conversion to negative implies effective penetration of bronchial mucosa or sputum (or both) by itraconazole, regardless of the concentrations of itraconazole that were...
View ArticleAdjunctive Therapy of Allergic Bronchopulmonary Aspergillosis with...
(2) the condition of all patients improved while receiving itraconazole; (3) the patient with the least impressive response to itraconazole had the lowest steady-state serum concentrations of the drug;...
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